Description

1-(4-Fluoro-2-Nitrophenyl)Ethanone is a specialized aromatic ketone building block featuring both fluoro and nitro substituents, which are key functional groups for directing further chemical transformations. This compound is valued for its role as a critical intermediate in the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for constructing novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and electron-withdrawing groups.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments where the nitro group is a key chromophore component.
• Organic Synthesis Reagent: A versatile substrate for palladium-catalyzed cross-coupling reactions, nucleophilic aromatic substitution (SNAr), and reduction reactions to yield valuable amino derivatives.

Basic Information

Product Name	1-(4-Fluoro-2-Nitrophenyl)Ethanone
CAS No.	1214346-44-7
Molecular Formula	C8H6FNO3
Molecular Weight	183.14 g/mol
Synonyms	1-(4-Fluoro-2-nitrophenyl)ethan-1-one; 4'-Fluoro-2'-nitroacetophenone; 2-Nitro-4-fluoroacetophenone; 4-Fluoro-2-nitroacetophenone; 1-Acetyl-4-fluoro-2-nitrobenzene; Ethanone, 1-(4-fluoro-2-nitrophenyl)-; Acetophenone, 4'-fluoro-2'-nitro-
EINECS	Contact for details

Quality Control

Our 1-(4-Fluoro-2-Nitrophenyl)Ethanone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, amber glass containers or foil-wrapped packaging is recommended for long-term storage.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.