Description

3-Nitro-5-(Trifluoromethyl)Picolinic Acid is a high-value, multi-functional heterocyclic building block characterized by its picolinic acid core substituted with both nitro and trifluoromethyl groups. This compound matters for its role as a critical intermediate in the synthesis of advanced agrochemicals and pharmaceuticals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key synthon for the development of next-generation herbicides, insecticides, and fungicides, leveraging the bioactivity of the trifluoromethyl and nitro-substituted pyridine ring.
• Pharmaceutical Building Block: Used in medicinal chemistry for the synthesis of drug candidates, particularly where the picolinic acid moiety can act as a metal chelator or the CF3 group enhances lipophilicity and metabolic resistance.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and coordination chemistry due to its carboxylic acid and nitrogen-containing heterocycle.
• Material Science Research: Employed in the development of advanced organic materials, such as liquid crystals or polymers, where its specific polarity and steric profile are advantageous.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated nitro-picolinate scaffold.

Basic Information

Item	Details
Product Name	3-Nitro-5-(Trifluoromethyl)Picolinic Acid
CAS No.	1214333-19-3
Molecular Formula	C7H3F3N2O4
Molecular Weight	236.11 g/mol
Synonyms	3-Nitro-5-(trifluoromethyl)pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 3-nitro-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-3-nitropicolinic acid; 3-Nitro-5-trifluoromethylpicolinic acid; Picolinic acid, 3-nitro-5-(trifluoromethyl)-; 1214333-19-3; 3-Nitro-5-(trifluoromethyl)-2-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 3-Nitro-5-(Trifluoromethyl)Picolinic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided with shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.