Description

1-Bromo-4-(Chloromethyl)-2-Fluorobenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling the precise introduction of bromo, chloromethyl, and fluoro substituents in a single molecule. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for constructing complex active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands used in transition metal catalysis and material science.
• Functional Material Precursor: Employed in the synthesis of monomers and polymers for advanced materials, including liquid crystals and organic semiconductors.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Chemical Research & Development: A valuable tool for medicinal and process chemistry in both academic and industrial R&D settings for exploring new synthetic pathways.

Basic Information

Product Name	1-Bromo-4-(Chloromethyl)-2-Fluorobenzene
CAS No.	1214322-98-1
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	2-Fluoro-4-bromobenzyl chloride; 4-Bromo-2-fluorobenzyl chloride; (4-Bromo-2-fluorophenyl)methyl chloride; 1-Bromo-4-(chloromethyl)-2-fluorobenzene; 4-Bromo-2-fluoro-α-chlorotoluene; α-Chloro-4-bromo-2-fluorotoluene; 2-Fluoro-α-chloro-4-bromotoluene
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-4-(Chloromethyl)-2-Fluorobenzene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade typically meets a purity specification of ≥97% (by GC/HPLC). Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.