Description

(1R)-1-(3,4-Dimethylphenyl)-2,2,2-Trifluoroethylamine is a high-purity chiral amine building block of significant interest in advanced organic synthesis. Its value lies in its unique stereochemistry and trifluoromethyl group, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(1R)-1-(3,4-Dimethylphenyl)-2,2,2-Trifluoroethylamine
CAS No.	1213968-93-4
Molecular Formula	C10H12F3N
Molecular Weight	203.20 g/mol
Synonyms	(R)-1-(3,4-Dimethylphenyl)-2,2,2-trifluoroethanamine; (R)-α-Methyl-3,4-dimethylbenzylamine Trifluoromethyl Derivative; (1R)-1-(3,4-Dimethylphenyl)-2,2,2-trifluoroethan-1-amine; (R)-3,4-Dimethyl-α-(trifluoromethyl)benzylamine; (R)-TFM-3,4-DMBA; (R)-1-(3,4-Xylyl)-2,2,2-trifluoroethylamine; (R)-Trifluoro(3,4-dimethylphenyl)ethylamine
EINECS	Contact for details

Quality Control

Our (1R)-1-(3,4-Dimethylphenyl)-2,2,2-Trifluoroethylamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with full characterization data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.