Description

(1R)-1-(2,3-Dimethylphenyl)-2,2,2-Trifluoroethylamine is a high-purity chiral amine building block of significant interest in advanced organic synthesis. Its value lies in its unique trifluoroethylamine moiety attached to a chiral, substituted aromatic core, making it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms and chiral center can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereochemistry in critical bond-forming reactions.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, fragrances, and advanced materials requiring specific stereochemical configurations.
• Academic and Industrial R&D: A valuable reference standard and building block in medicinal chemistry and process chemistry research for exploring new synthetic pathways.

Basic Information

Product Name	(1R)-1-(2,3-Dimethylphenyl)-2,2,2-Trifluoroethylamine
CAS No.	1212827-33-2
Molecular Formula	C10H12F3N
Molecular Weight	203.20 g/mol
Synonyms	(1R)-1-(2,3-Dimethylphenyl)-2,2,2-trifluoroethanamine; (R)-1-(2,3-Dimethylphenyl)-2,2,2-trifluoroethylamine; (1R)-1-(2,3-Xylyl)-2,2,2-trifluoroethylamine; (R)-α-(2,3-Dimethylphenyl)-2,2,2-trifluoroethylamine; (1R)-2,2,2-Trifluoro-1-(2,3-dimethylphenyl)ethanamine; TFMPEA derivative (chiral); Chiral Trifluoroethylamine Building Block
EINECS	Contact for details

Quality Control

Our (1R)-1-(2,3-Dimethylphenyl)-2,2,2-Trifluoroethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.