Description

3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery, ligand synthesis, and functional polymer development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific halogenated aromatic structures.
• Material Science: Serves as a monomer or functionalization agent in the production of organic electronic materials, such as OLEDs and conductive polymers.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis and organometallic complexes.
• Chemical Biology Probes: Utilized to create tagged molecules and bioconjugates for imaging, diagnostics, and proteomics research.
• Custom Synthesis & Contract Manufacturing: A versatile starting material for custom chemical synthesis services targeting niche and proprietary compounds.

Basic Information

Product Name	3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1212021-11-8
Molecular Formula	C13H15BClNO2
Molecular Weight	263.53 g/mol
Synonyms	3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; (3-Cyano-5-chlorophenyl)boronic acid pinacol ester; 3-Chloro-5-(pinacolatoboryl)benzonitrile; 5-Chloro-3-cyanophenylboronic acid pinacol ester; 3-Chloro-5-cyanophenylboronic acid pinacol ester; 1212021-11-8; Pinacol (3-cyano-5-chlorophenyl)boronate
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to consistent quality and traceability supports your R&D and production needs with reliable, specification-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronic ester moiety. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.