Description

6-(Difluoromethoxy)Nicotinaldehyde is a high-purity, versatile chemical intermediate featuring a nicotinaldehyde core substituted with a difluoromethoxy group. This compound matters for its role as a critical building block in modern synthetic chemistry, enabling the introduction of both pyridine and fluorine-containing motifs into target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating novel pyridine-based ligands used in catalysis and material science applications.
• Fluorinated Building Block: Employed in medicinal chemistry to incorporate fluorine atoms into drug-like molecules, a common strategy to improve potency, membrane permeability, and pharmacokinetic properties.
• Chemical Research: Utilized in academic and industrial R&D for exploring new heterocyclic compounds and reaction methodologies.

Basic Information

Product Name	6-(Difluoromethoxy)Nicotinaldehyde
CAS No.	1211577-99-9
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	6-(Difluoromethoxy)pyridine-3-carbaldehyde; 3-Pyridinecarboxaldehyde, 6-(difluoromethoxy)-; Nicotinaldehyde, 6-(difluoromethoxy)-; 6-Difluoromethoxynicotinaldehyde; 5-Formyl-2-(difluoromethoxy)pyridine
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)Nicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.