Description

n-[(1R,2R)-2-(1-Piperidinyl)Cyclohexyl]-N′-[4-(Trifluoromethyl)Phenyl]Squaramide is a high-purity, stereochemically defined squaramide derivative that serves as a potent and selective organocatalyst. This compound is valued for its ability to facilitate challenging asymmetric transformations with high enantioselectivity and yield under mild conditions. It is primarily sought by research institutions and pharmaceutical companies engaged in advanced synthetic chemistry, process development, and the discovery of novel therapeutic agents.

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst for enantioselective Michael additions, Mannich reactions, and other C-C bond-forming processes.
• Pharmaceutical Intermediate Synthesis: Used in the research and development stages for constructing complex, chiral molecular scaffolds found in active pharmaceutical ingredients (APIs).
• Methodology Development: A key reagent for chemists developing new catalytic protocols and exploring reaction mechanisms in academic and industrial R&D laboratories.
• Ligand and Catalyst Screening: Serves as a benchmark or lead compound in high-throughput screening for novel catalytic activities.
• Chemical Biology Probes: Potential use in the design of molecular probes to study enzyme inhibition or biological recognition events due to its specific hydrogen-bonding motifs.

Basic Information

Product Name	n-[(1R,2R)-2-(1-Piperidinyl)Cyclohexyl]-N′-[4-(Trifluoromethyl)Phenyl]Squaramide
CAS No.	1211565-08-0
Molecular Formula	C24H32F3N3O2
Molecular Weight	451.53 g/mol
Synonyms	(1R,2R)-N-(2-(Piperidin-1-yl)cyclohexyl)-4-((4-(trifluoromethyl)phenyl)amino)-3-cyclobutene-1,2-dione-3-amine; (R,R)-Squaramide Catalyst; (1R,2R)-2-(Piperidin-1-yl)cyclohexanamine squaramide derivative; Chiral Squaramide Organocatalyst; Bifunctional Squaramide Catalyst; (R,R)-2-(1-Piperidinyl)cyclohexylamine-based squaramide; N-((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione
EINECS	Contact for details

Quality Control

Our n-[(1R,2R)-2-(1-Piperidinyl)CycloHexyl]-N′-[4-(Trifluoromethyl)Phenyl]Squaramide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles. We adhere to relevant standards for research chemicals, ensuring reliable performance in sensitive catalytic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.