Description

4-(Pentafluorosulfur)Benzenesulfonyl Chloride is a high-value, specialty organosulfur and organofluorine compound. This chemical serves as a critical sulfonylation reagent and a versatile building block for introducing the unique pentafluorosulfanyl (SF5) functional group into target molecules. It is primarily utilized by pharmaceutical and agrochemical research and development teams seeking to enhance the metabolic stability, lipophilicity, and overall bioactivity of novel compounds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing the pentafluorosulfanyl group, known to improve drug-like properties.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the SF5 moiety can increase efficacy and environmental stability.
• Material Science Research: Serves as a precursor for creating specialty polymers, liquid crystals, and electronic materials with unique fluorinated properties.
• Sulfonamide Library Production: Essential reagent for high-throughput synthesis of diverse sulfonamide compounds for biological screening in drug discovery.
• Chemical Biology Probes: Employed in the design of molecular probes and labeling agents that leverage the distinct spectroscopic signature of the SF5 group.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke fluorinated compound synthesis services.

Basic Information

Item	Details
Product Name	4-(Pentafluorosulfur)Benzenesulfonyl Chloride
CAS No.	1211516-26-5
Molecular Formula	C6H2ClF5O2S2
Molecular Weight	292.66 g/mol
Synonyms	p-(Pentafluorosulfur)Benzenesulfonyl Chloride; 4-SF5-Benzenesulfonyl Chloride; 1-(Chlorosulfonyl)-4-(pentafluoro-λ6-sulfanyl)benzene; Benzenesulfonyl chloride, 4-(pentafluorosulfur)-; SF5-Ph-SO2Cl; 4-(SF5)C6H4SO2Cl
EINECS	Contact for details

Quality Control

Our production of 4-(Pentafluorosulfur)Benzenesulfonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including NMR (1H, 19F, 13C), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.