Description

5-Bromo-2-(trifluoromethyl)thiazole is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing the thiazole core and fluorine atoms into target molecules, which are critical for modulating their physicochemical and biological properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in antiviral, anticancer, and anti-inflammatory research pipelines.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Material Science: Serves as a precursor for functionalized polymers, liquid crystals, and electronic materials requiring specific fluorine-containing motifs.
• Chemical Biology: Employed as a probe or labeling agent in biochemical studies due to its reactive bromine handle for further derivatization.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Fluorine Chemistry Library Building: A valuable starting material for constructing diverse compound libraries aimed at drug discovery and optimization.

Basic Information

Product Name	5-Bromo-2-(trifluoromethyl)thiazole
CAS No.	1209458-88-7
Molecular Formula	C4HBrF3NS
Molecular Weight	232.02 g/mol
Synonyms	2-(Trifluoromethyl)-5-bromothiazole; 5-Bromo-2-trifluoromethylthiazole; Thiazole, 5-bromo-2-(trifluoromethyl)-; 5-Bromo-2-(trifluoromethyl)-1,3-thiazole; 1209458-88-7
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(trifluoromethyl)thiazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.