Description

1-Chloro-2,4-Difluoro-3-Iodobenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring chlorine, fluorine, and iodine substituents, makes it a versatile and valuable intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, leveraging its halogenated benzene core.
• Material Science Precursor: Serves as a monomer or precursor in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine and chlorine atoms provide excellent handles for versatile metal-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Buchwald-Hartwig aminations.
• Fluorine Chemistry Research: An essential substrate for studying nucleophilic aromatic substitution and other reactions involving fluorine atoms in an electron-deficient ring.
• Ligand and Catalyst Development: Used to synthesize complex chelating ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	1-Chloro-2,4-Difluoro-3-Iodobenzene
CAS No.	1208078-26-5
Molecular Formula	C6H2ClF2I
Molecular Weight	274.44 g/mol
Synonyms	3-Iodo-1-chloro-2,4-difluorobenzene; 2,4-Difluoro-1-chloro-3-iodobenzene; 1-Chloro-3-iodo-2,4-difluorobenzene; 3-Chloro-2,6-difluoroiodobenzene; Benzene, 1-chloro-2,4-difluoro-3-iodo-; CAS 1208078-26-5
EINECS	Contact for details

Quality Control

Our 1-Chloro-2,4-Difluoro-3-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.