Description

2-Bromo-1,4-difluoro-3-iodobenzene is a highly functionalized halogenated benzene derivative, serving as a critical multi-halogen synthon in advanced organic synthesis. Its unique substitution pattern makes it an indispensable building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for its versatility in cross-coupling reactions and functional group transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those requiring halogenated aromatic cores for bioactivity or further functionalization.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides where the difluoro and iodo substituents impart specific biological properties.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) precursors and liquid crystals, due to its halogenated aromatic structure.
• Cross-Coupling Reactions: Serves as a versatile substrate in Suzuki, Stille, and Negishi couplings, where the bromo and iodo groups offer orthogonal reactivity for sequential functionalization.
• Ligand and Catalyst Development: Utilized as a building block for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Acts as a starting material for creating halogen-tagged molecular probes and biomarkers for imaging and diagnostic applications.

Basic Information

Product Name	2-Bromo-1,4-difluoro-3-iodobenzene
CAS No.	1208074-72-9
Molecular Formula	C6H2BrF2I
Molecular Weight	318.89 g/mol
Synonyms	1-Bromo-2,5-difluoro-4-iodobenzene; 3-Iodo-2-bromo-1,4-difluorobenzene; Benzene, 2-bromo-1,4-difluoro-3-iodo-; 2-Bromo-1,4-difluoro-3-iodo-benzene; 2-Bromo-3-iodo-1,4-difluorobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-1,4-difluoro-3-iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.