Description

(S)-tert-Butyl 2-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazol-2-Yl)Pyrrolidine-1-Carboxylate is a high-value, chiral boronic ester derivative that serves as a critical synthetic intermediate. Its primary value lies in enabling the construction of complex molecules through versatile cross-coupling reactions, particularly Suzuki-Miyaura couplings. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of chiral drug candidates, especially those containing a benzimidazole-pyrrolidine core.
• Suzuki-Miyaura Cross-Coupling: Used as a boronic ester coupling partner to introduce the substituted benzimidazole fragment into complex molecular architectures.
• Agrochemical Research: Intermediate in the development of novel pesticides and herbicides requiring specific stereochemistry.
• Ligand & Catalyst Development: Precursor for creating chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Exploration: Potential monomer or precursor for advanced organic electronic materials.
• Academic & Contract Research: Enables medicinal chemistry programs and method development in academic and CRO laboratories.

Basic Information

Item	Details
Product Name	(S)-tert-Butyl 2-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazol-2-Yl)Pyrrolidine-1-Carboxylate
CAS No.	1208009-37-3
Molecular Formula	C24H36BN3O4
Molecular Weight	441.38 g/mol
Synonyms	(S)-1-Boc-2-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine; (S)-tert-Butyl 2-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzoimidazol-2-yl)pyrrolidine-1-carboxylate; (S)-1-(tert-Butoxycarbonyl)-2-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]pyrrolidine; (S)-2-(6-BPin-1H-benzoimidazol-2-yl)-1-Boc-pyrrolidine; 1208009-37-3; (S)-Boc-Protected Boronic Ester Benzimidazole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data including HPLC purity, chiral purity, and NMR confirmation. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.