Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One is a high-value pharmaceutical intermediate and key building block in modern organic synthesis. Its core value lies in its role as a versatile boronic ester pinacol ester, enabling efficient Suzuki-Miyaura cross-coupling reactions to construct complex heterocyclic scaffolds. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel kinase inhibitors and other biologically active small molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of targeted drug candidates, especially for oncology and CNS diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to form carbon-carbon bonds between the pyrrolopyridinone core and various aryl or heteroaryl halides.
• Kinase Inhibitor Development: Serves as a key building block for constructing potent and selective kinase inhibitor libraries.
• Agrochemical Research: Employed in the discovery of new active ingredients with complex heterocyclic structures.
• Material Science: Potential use in the synthesis of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Can be utilized for creating molecular probes and affinity tags.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One
CAS No.	1207623-97-9
Molecular Formula	C13H17BN2O3
Molecular Weight	260.10 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 2-Oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-5-boronic acid pinacol ester; 1,3-Dihydro-2H-pyrrolo[2,3-b]pyridin-2-one, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-(Pinacolboron)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-one; 5-Borono-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one pinacol ester; CAS 1207623-97-9
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the container should be stored in a cool, dry place, ideally under an inert atmosphere such as nitrogen or argon for long-term storage. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.