Description

6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole is a high-value, multi-functional indole-based boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and advanced materials research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated indole-based drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated indole scaffold.
• Material Science & OLED Development: Serves as a building block for creating novel organic semiconductors, fluorescent dyes, and electron-transport materials used in organic light-emitting diodes (OLEDs) and sensors.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and tool compounds for studying biological pathways and enzyme functions.
• Library Synthesis for Drug Discovery: Facilitates the rapid parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry campaigns.
• Cross-Coupling Methodology Research: Used as a standard or model substrate in academic and industrial laboratories to develop and optimize new catalytic systems and synthetic protocols.

Basic Information

Product Name	6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
CAS No.	1207623-96-8
Molecular Formula	C₁₄H₁₇BFNO₂
Molecular Weight	261.10 g/mol
Synonyms	6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 6-Fluoro-1H-indole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluoro-1H-indole; 6-Fluoro-5-(pinacolatoboryl)-1H-indole; 6-Fluoroindole-5-boronic acid pinacol ester; 1H-Indole-5-boronic acid, 6-fluoro-, 1,1,1,1-tetramethyl-2,2-diethyl ester (9CI); PINACOL 6-FLUORO-1H-INDOLE-5-BORONATE
EINECS	Contact for details

Quality Control

Our 6-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.