Description

1H-Indole, 4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional chemical building block that combines an indole scaffold with a boronic ester pinacol group. This compound is specifically engineered for advanced pharmaceutical and agrochemical research, serving as a critical intermediate in the synthesis of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for applications such as Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides and fungicides that require fluorinated indole structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials and advanced polymers with specific optoelectronic properties.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronic ester moiety makes it an ideal partner for palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl bonds.
• Chemical Biology Probes: Utilized in the development of fluorescent probes and molecular tags for studying biological processes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and library production for client projects.

Basic Information

Product Name	1H-Indole, 4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1207623-95-7
Molecular Formula	C14H17BFNO2
Molecular Weight	261.10 g/mol
Synonyms	4-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 4-Fluoro-1H-indole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-fluoro-1H-indole; 4-Fluoro-5-indolylboronic acid pinacol ester; 4-Fluoro-1H-indol-5-ylboronic acid pinacol ester; 4-Fluoro-5-(pinacolboron)-1H-indole
EINECS	Contact for details

Quality Control

Our production of 1H-Indole, 4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized by NMR (1H, 13C, 19F, 11B), HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive (hygroscopic) nature. Allow the sealed container to reach ambient temperature before opening to prevent condensation and hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.