Description

1-Bromo-5-Fluoroisoquinoline is a high-value, halogenated isoquinoline derivative serving as a critical building block in advanced organic synthesis. Its core value proposition lies in providing a versatile scaffold for constructing complex molecules, particularly in the development of novel pharmaceuticals and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require precise, high-purity intermediates for their synthetic pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity of the fluorinated isoquinoline core.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a tagging or cross-linking reagent in probe development for studying enzyme mechanisms and protein interactions.
• Cross-Coupling Reactions: Acts as a superior electrophilic partner in palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations for carbon-carbon and carbon-heteroatom bond formation.
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries via parallel and combinatorial chemistry in high-throughput screening campaigns.

Basic Information

Product Name	1-Bromo-5-Fluoroisoquinoline
CAS No.	1207448-30-3
Molecular Formula	C9H5BrFN
Molecular Weight	226.05 g/mol
Synonyms	5-Fluoro-1-bromoisoquinoline; 1-Bromo-5-fluoro-isoquinoline; Isoquinoline, 1-bromo-5-fluoro-; 1207448-30-3; 5-Fluoro-1-bromoisoquinoline; 1-Bromo-5-fluoroisoquinoline; 1-Bromo-5-fluoro-isoquinoline; 5-Fluoro-1-bromo-isoquinoline
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Fluoroisoquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.