Description

2H-Pyran-4-Carbonitrile, Tetrahydro-4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound matters because it serves as a critical building block in modern synthetic chemistry, enabling key carbon-carbon bond-forming reactions like the Suzuki-Miyaura cross-coupling. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) via cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring boronic ester chemistry.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for constructing biaryl and heterobiaryl structures central to many functional compounds.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and labeled compounds for biochemical and diagnostic research.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands and organometallic catalysts.

Basic Information

Product Name	2H-Pyran-4-Carbonitrile, Tetrahydro-4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-
CAS No.	1206640-91-6
Molecular Formula	C18H24BNO3
Molecular Weight	313.20 g/mol
Synonyms	4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carbonitrile; Tetrahydro-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2H-pyran-4-carbonitrile; 4-(4-(Pinacolboryl)phenyl)tetrahydro-2H-pyran-4-carbonitrile; 4-(4-Boronophenyl)tetrahydro-2H-pyran-4-carbonitrile pinacol ester; 1206640-91-6; (4-(4-Cyanotetrahydro-2H-pyran-4-yl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2H-Pyran-4-Carbonitrile, Tetrahydro-4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- is produced and analyzed under strict quality management protocols to ensure high purity and consistency for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.