Description

1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Piperazin-1-Yl)Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the efficient formation of carbon-carbon bonds between aromatic rings, enabling the construction of complex molecular architectures.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that require specific biaryl motifs for optimal activity.
• Material Science: Potential building block for creating organic electronic materials, such as those used in OLEDs or organic photovoltaics, due to its conjugated aromatic system.
• Chemical Biology & Proteomics: Can be utilized in the development of molecular probes and activity-based protein profiling (ABPP) agents for target identification and validation.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening (HTS) campaigns in early-stage drug discovery.

Basic Information

Product Name	1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Piperazin-1-Yl)Ethanone
CAS No.	1206594-13-9
Molecular Formula	C19H29BN2O3
Molecular Weight	344.26 g/mol
Synonyms	1-[4-[[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]piperazin-1-yl]ethanone; 1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazin-1-yl)ethan-1-one; 2-[4-[(4-Acetylpiperazin-1-yl)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-(4-(4-(Pinacolboryl)benzyl)piperazin-1-yl)ethanone; Acetyl Piperazine Boronic Ester Derivative; 1206594-13-9; BRN 14810917
EINECS	Contact for details

Quality Control

Our production of 1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Piperazin-1-Yl)Ethanone adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the exacting standards required for pharmaceutical R&D and scale-up. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.