Description

2-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Indazole is a high-value, heterocyclic boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries seeking to construct complex molecular architectures with precision.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Development: Used in constructing active ingredients for crop protection agents and herbicides.
• Material Science: Serves as a precursor in the synthesis of organic semiconductors, OLED materials, and conductive polymers.
• Chemical Biology: Employed in the development of molecular probes and bioconjugation reagents.
• Academic & Contract Research: A versatile reagent for methodology development and library synthesis in research laboratories.
• Scale-Up Process Chemistry: Suitable for use in pilot plant and commercial-scale API manufacturing where robust coupling partners are required.

Basic Information

Product Name	2-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Indazole
CAS No.	1204580-79-9
Molecular Formula	C₁₄H₁₉BN₂O₂
Molecular Weight	258.13 g/mol
Synonyms	2-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-2H-indazole; 2-Methyl-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole; 2H-Indazole, 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1204580-79-9; 2-Methyl-6-(pinacolatoboryl)-2H-indazole; 6-Pinacolatoboryl-2-methyl-2H-indazole
EINECS	Contact for details

Quality Control

Our 2-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Indazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.