Description

3,5-Bis(Trifluoromethyl)-1H-Pyrazole-4-Boronic Acid, Pinacol Ester is a high-value organoboron building block, specifically a protected boronic acid ester, designed for advanced cross-coupling reactions. This compound is critical for pharmaceutical and agrochemical research, enabling the efficient synthesis of complex molecules containing the biologically active 3,5-bis(trifluoromethyl)pyrazole scaffold. It is primarily utilized by medicinal chemists and process development scientists in the life sciences industry for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-couplings for synthesizing drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides that leverage the stability and lipophilicity of the trifluoromethyl groups.
• Material Science Research: Serves as a building block for creating advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers.
• Ligand and Catalyst Development: Employed in the synthesis of novel pyrazole-based ligands for transition metal catalysis and organometallic chemistry.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis organizations (CSOs) and CDMOs (Contract Development and Manufacturing Organizations) serving the global pharmaceutical pipeline.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)-1H-Pyrazole-4-Boronic Acid, Pinacol Ester
CAS No.	1204334-20-2
Molecular Formula	C12H13BF6N2O2
Molecular Weight	342.05 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-bis(trifluoromethyl)-1H-pyrazole; 3,5-Bis(trifluoromethyl)-1H-pyrazole-4-boronic acid pinacol ester; 3,5-Bis(trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole-4-boronic acid, 3,5-bis(trifluoromethyl)-, 1,1-dimethylethyl ester; B-3,5-Bis(trifluoromethyl)-1H-pyrazol-4-ylboronic acid pinacol ester; 4-Borono-3,5-bis(trifluoromethyl)pyrazole pinacol ester
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)-1H-Pyrazole-4-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.