Description

(E)-3-(6-Bromopyridin-2-Yl)Acrylaldehyde CAS NO 1204306-43-3 is a high-purity, versatile brominated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a bromo-substituted pyridine ring and an α,β-unsaturated aldehyde (acrylaldehyde) group, makes it an invaluable electrophilic intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Material Science & OLED Development: Acts as a building block for creating organic ligands and complex heterocyclic compounds used in electronic materials and light-emitting diodes.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form new carbon-carbon bonds.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and labeled compounds for biochemical research.
• Academic & Contract Research: Serves as a specialized reagent for methodological development and novel synthetic route exploration in academic and industrial R&D laboratories.

Basic Information

Item	Detail
Product Name	(E)-3-(6-Bromopyridin-2-Yl)Acrylaldehyde
CAS No.	1204306-43-3
Molecular Formula	C8H6BrNO
Molecular Weight	212.05 g/mol
Synonyms	(E)-3-(6-Bromopyridin-2-yl)acrylaldehyde; 2-Bromo-6-[(1E)-2-formylethenyl]pyridine; 3-(6-Bromopyridin-2-yl)acrylaldehyde; (E)-3-(6-Bromo-2-pyridyl)acrylaldehyde; 6-Bromo-2-pyridineacrolein; (E)-3-(6-Bromopyridin-2-yl)propenal; (E)-3-(6-Bromo-2-pyridinyl)-2-propenal
EINECS	Contact for details

Quality Control

Our (E)-3-(6-Bromopyridin-2-Yl)Acrylaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We are committed to meeting the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its properties of being easily oxidized, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term storage. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.