Description

8-Fluoro-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the fluorine atom and the tetrahydroisoquinoline scaffold are critical for modulating biological activity and physicochemical properties. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors focused on creating new molecules with enhanced efficacy and selectivity.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Development: Used in the research and production of advanced pesticides and herbicides, where the fluorine substituent can improve metabolic stability and bioavailability.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for asymmetric catalysis and metal complexes.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and advanced polymers.

Basic Information

Product Name	8-Fluoro-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1203683-58-2
Molecular Formula	C11H14FN
Molecular Weight	179.24 g/mol
Synonyms	8-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-8-fluoro-4,4-dimethylisoquinoline; 4,4-Dimethyl-8-fluoro-1,2,3,4-tetrahydroisoquinoline; 8-Fluoro-4,4-dimethyl-3,4-dihydro-1H-isoquinoline; 1203683-58-2; 8-Fluoro-4,4-DMTIQ
EINECS	Contact for details

Quality Control

Our 8-Fluoro-4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.