Description

4,4-Dimethyl-5-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring a tetrahydroisoquinoline core with a trifluoromethyl group, makes it a critical intermediate for developing novel compounds with enhanced biological activity and physicochemical properties. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries seeking to incorporate fluorine atoms into lead molecules to improve metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: Serves as a key scaffold in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, oncology, and anti-infective therapies.
• Agrochemical Research: Used in developing new-generation pesticides and herbicides, where the trifluoromethyl group can enhance lipophilicity and environmental stability.
• Material Science Precursor: Acts as a building block for specialty chemicals, liquid crystals, and advanced organic materials requiring fluorinated components.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for lead optimization and patent generation.
• Fluorine Chemistry: A valuable reagent for chemists exploring novel fluorination methodologies and the synthesis of complex fluorinated heterocycles.

Basic Information

Product Name	4,4-Dimethyl-5-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1203682-64-7
Molecular Formula	C12H14F3N
Molecular Weight	229.24 g/mol
Synonyms	5-(Trifluoromethyl)-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline; 4,4-Dimethyl-5-(trifluoromethyl)-3,4-dihydro-1H-isoquinoline; 4,4-Dimethyl-5-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-4,4-dimethyl-5-(trifluoromethyl)isoquinoline
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl-5-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports your R&D and scale-up processes with reliable, traceable material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.