Description

Benzenamine, 4-[[6-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro- is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and targeted therapies. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted cancer therapeutics and other high-value small molecule drugs.
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry & Scale-Up: Serves as a key raw material for process research, route scouting, and pilot-scale manufacturing of clinical trial materials.
• Contract Manufacturing: Supplied to CDMOs for the production of APIs under current Good Manufacturing Practice (cGMP) standards.
• Biochemical Research: Employed as a tool compound in biochemical assays to study specific enzyme inhibition or receptor binding.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	Benzenamine, 4-[[6-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoro-
CAS No.	1203656-90-9
Molecular Formula	C15H7ClF5N3O
Molecular Weight	375.68 g/mol
Synonyms	4-[[6-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]-3,5-difluoroaniline; 3,5-Difluoro-4-((6-chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)aniline; 4-((6-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3,5-difluorobenzenamine; 1H-Pyrrolo[2,3-b]pyridine, 4-((4-amino-2,6-difluorophenoxy)-6-chloro-3-(trifluoromethyl)-; Key Intermediate for Lorlatinib analogs; Advanced Fluorinated Pyrrolopyridine Intermediate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring compliance with the stringent requirements of pharmaceutical R&D and manufacturing. Our quality protocols are designed to support regulatory filings, and we can supply material suitable for use under current Good Manufacturing Practice (cGMP) guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.