Description

2-(Ethoxycarbonylmethylamino)Pyrimidine-5-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and a key building block in modern synthetic chemistry. This compound is specifically designed for use in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is an essential reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used to create novel pyrimidine-based compounds for crop protection and pesticide development.
• Material Science: Serves as a building block for organic electronic materials, such as those used in OLEDs and semiconductors.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds with high selectivity.
• Chemical Biology: Utilized in the development of molecular probes and labeled compounds for biochemical research.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs for bespoke chemical synthesis projects.

Basic Information

Product Name	2-(Ethoxycarbonylmethylamino)Pyrimidine-5-Boronic Acid, Pinacol Ester
CAS No.	1202805-23-9
Molecular Formula	C14H22BN3O4
Molecular Weight	307.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[(ethoxycarbonyl)methylamino]pyrimidine; 2-[(Ethoxycarbonyl)methylamino]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-(N-Ethoxycarbonylmethyl)amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-(Ethoxycarbonylmethylamino)pyrimidine-5-boronic acid pinacol ester; Pyrimidine-5-boronic acid, 2-[(ethoxycarbonyl)methylamino]-, 1,1-dimethylethyl ester; Boronic acid, B-[2-[[(ethoxycarbonyl)methyl]amino]-5-pyrimidinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-(Ethoxycarbonylmethylamino)Pyrimidine-5-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.