Description

4-(4-Nitro-Pyrazol-1-Yl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a tert-butyloxycarbonyl (Boc) group and functionalized with a nitropyrazole moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas like kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic targets.
• Kinase Inhibitor Development: The nitropyrazole-piperidine scaffold is valuable for creating potential inhibitors for various kinase targets involved in oncology and inflammatory diseases.
• Custom Synthesis: Serves as a starting material or intermediate for contract manufacturing organizations (CMOs) specializing in custom chemical synthesis.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological pathways and target validation.
• Process Chemistry: Employed in route scouting and scale-up development for efficient manufacturing processes of target molecules.

Basic Information

Product Name	4-(4-Nitro-Pyrazol-1-Yl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1201916-87-1
Molecular Formula	C13H20N4O4
Molecular Weight	296.32 g/mol
Synonyms	1-Boc-4-(4-nitropyrazol-1-yl)piperidine; tert-Butyl 4-(4-nitropyrazol-1-yl)piperidine-1-carboxylate; 4-(4-Nitro-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester; 1-(1-tert-Butoxycarbonyl-4-piperidinyl)-4-nitro-1H-pyrazole; 4-(4-Nitro-1-pyrazolyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-4-(4-nitro-1H-pyrazol-1-yl)piperidine; 4-(4-Nitropyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-(4-Nitro-Pyrazol-1-Yl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.