Description

{3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Propyl}-Carbamic Acid tert-Butyl Ester is a sophisticated boronic ester derivative, serving as a crucial protected intermediate in modern synthetic chemistry. Its primary value lies in enabling the controlled synthesis of complex molecules, particularly through Suzuki-Miyaura cross-coupling reactions, which are fundamental to pharmaceutical and advanced material research. This compound is essential for R&D chemists and process development scientists working in pharmaceutical development, agrochemical discovery, and the creation of organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: The protected boronic ester functionality allows for selective and efficient carbon-carbon bond formation under mild conditions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aromatic architectures.
• Material Science Research: Intermediate in the synthesis of organic semiconductors, liquid crystals, and polymers for electronic applications.
• Chemical Biology & Proteolysis-Targeting Chimeras (PROTACs): Serves as a versatile linker or component in the design of bifunctional molecules for targeted protein degradation.
• Custom Synthesis & Contract Manufacturing: A high-value starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	{3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Propyl}-Carbamic Acid tert-Butyl Ester
CAS No.	1201790-19-3
Molecular Formula	C20H32BNO5
Molecular Weight	377.29 g/mol
Synonyms	tert-Butyl N-[3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propyl]carbamate; 3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propylcarbamic Acid tert-Butyl Ester; BOC-Protected Aminopropyloxy Phenylboronic Acid Pinacol Ester; 4-(3-((tert-Butoxycarbonyl)amino)propoxy)phenylboronic Acid Pinacol Ester; N-BOC-3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propan-1-amine
EINECS	Contact for details

Quality Control

Our {3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Propyl}-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.