Description

n-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinamide is a high-value boronic ester derivative of nicotinamide, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates targeting a range of therapeutic areas, including oncology and central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Facilitates the creation of organic electronic materials, such as those used in OLEDs and organic photovoltaics, through controlled cross-coupling.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and for the development of enzyme inhibitors.
• Academic & R&D: A versatile reagent for methodological development in synthetic organic chemistry laboratories worldwide.
• Custom Synthesis: Serves as a starting point for contract research organizations (CROs) and CDMOs to produce bespoke compounds for client projects.

Basic Information

Product Name	n-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinamide
CAS No.	1201644-52-1
Molecular Formula	C16H23BN2O3
Molecular Weight	302.18 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopropylnicotinamide; Nicotinamide, N-cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1201644-52-1; 5-Pinacolatoboron-N-cyclopropylnicotinamide; N-Cyclopropyl-5-(pinacolatoboryl)nicotinamide; 3-Cyclopropylcarbamoylpyridine-5-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Due to its hygroscopic and easily oxidized nature, the container should be kept sealed and allowed to reach room temperature before opening to minimize moisture ingress. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.