Description

3-Pyridinamine, n-(1-Methylethyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a specialized boronic ester derivative of a substituted pyridinamine, serving as a key synthetic intermediate. This compound is valued for its role in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. It is primarily required by R&D and production teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in creating complex heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific pyridine-based structures.
• Material Science Research: Serves as a precursor for developing organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic semiconductors.
• Cross-Coupling Reactions: Specifically designed as a boron reagent in palladium-catalyzed Suzuki-Miyaura couplings to form new carbon-carbon bonds.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug candidates through structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Item	Details
Product Name	3-Pyridinamine, n-(1-Methylethyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1201644-38-3
Molecular Formula	C14H23BN2O2
Molecular Weight	262.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-isopropylpyridin-3-amine; N-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine; 3-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-isopropylpyridine; Boronic acid, B-[3-[(1-methylethyl)amino]-5-pyridinyl]-, 1,3-propanediol cyclic ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-isopropylaminopyridine
EINECS	Contact for details

Quality Control

Our 3-Pyridinamine boronic ester is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.