Description

5-Methoxy-1-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is a high-value, protected boronic ester derivative of a substituted indole, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to build novel molecular architectures for drug candidates, active ingredients, and functional organic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in constructing complex heterocyclic cores prevalent in CNS-active and oncology-targeted molecules.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, enabling the introduction of the indole moiety into lead structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers.
• Chemical Biology & Probe Development: Utilized in the synthesis of fluorescent tags, molecular probes, and bioconjugates for studying biological systems.
• Academic & Contract Research: A valuable reagent for methodology development and complex natural product synthesis in academic and industrial R&D laboratories.
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale synthesis due to the stability offered by the pinacol boronate ester protecting group.

Basic Information

Product Name	5-Methoxy-1-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	1201189-40-3
Molecular Formula	C16H22BNO3
Molecular Weight	287.16 g/mol
Synonyms	1-Methyl-5-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methoxy-1-methyl-1H-indole; 5-Methoxy-1-methyl-1H-indole-3-boronic acid pinacol ester; 1-Methyl-5-methoxyindole-3-boronic acid pinacol ester; 5-MeO-1-Me-3-Bpin-indole; CAS 1201189-40-3
EINECS	Contact for details

Quality Control

Our 5-Methoxy-1-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for advanced synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.