Description

Ethyl 2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is a high-purity, synthetically valuable boronic ester derivative, widely recognized by its CAS number 1198615-67-6. This compound serves as a critical advanced pharmaceutical intermediate and building block in modern organic synthesis, particularly for the construction of complex molecules via Suzuki-Miyaura cross-coupling reactions. It is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality precursors for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds to create complex biaryl structures, a fundamental transformation in medicinal chemistry and material science.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the difluoro and boronate functionalities impart specific biological activity and stability.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor for creating fluorinated aromatic components in advanced electronic and display materials.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity boronic esters.

Basic Information

Product Name	Ethyl 2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	1198615-67-6
Molecular Formula	C₁₅H₁₉BF₂O₄
Molecular Weight	312.12 g/mol
Synonyms	2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid ethyl ester; Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-difluorobenzoate; 4-Borono-2,6-difluorobenzoic acid ethyl ester, pinacol ester; 1198615-67-6; 2,6-Difluoro-4-(pinacolatoboron)benzoic acid ethyl ester; Ethyl 2,6-difluoro-4-(pinacolatoboron)benzoate; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-difluorobenzoic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Every batch of our Ethyl 2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.