Description

Methyl 2-Amino-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is a high-purity, advanced pharmaceutical intermediate featuring a valuable boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development and scalable synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly those containing biphenyl or heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aromatic rings, essential for constructing molecular frameworks in drug discovery.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science: Serves as a precursor for organic semiconductors, OLED materials, and other functional polymers where precise molecular architecture is required.
• Chemical Synthesis: A versatile reagent in academic and industrial R&D for creating diverse libraries of boronic acid derivatives and complex organic molecules.

Basic Information

Product Name	Methyl 2-Amino-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	1198615-60-9
Molecular Formula	C14H20BNO4
Molecular Weight	277.13 g/mol
Synonyms	2-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 2-amino-4-(pinacolatoboron)benzoate; 4-Pinacolatoboranyl-2-aminobenzoic acid methyl ester; 2-Amino-4-(pinacolboronato)methyl benzoate; Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anthranilate; CAS 1198615-60-9; 4-Borono-2-aminobenzoic acid methyl ester pinacol ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.