Description

2-Chloro-4-Iodo-1-(Trifluoromethoxy)Benzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique trifluoromethoxy and halogen substituents, which are critical for modulating the electronic and steric properties of target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Fluorine Chemistry: An important reagent for introducing the trifluoromethoxy group into molecular scaffolds, a moiety known to improve metabolic stability and lipophilicity.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2-Chloro-4-Iodo-1-(Trifluoromethoxy)Benzene
CAS No.	1198422-69-3
Molecular Formula	C7H3ClF3IO
Molecular Weight	321.45 g/mol
Synonyms	1-Chloro-3-iodo-4-(trifluoromethoxy)benzene; 2-Chloro-4-iodo-α,α,α-trifluoroanisole; 4-Chloro-2-iodo-1-(trifluoromethoxy)benzene; 2-Chloro-4-iodophenyl trifluoromethyl ether; 1-(Trifluoromethoxy)-2-chloro-4-iodobenzene; OCF3-Benzene, 2-chloro-4-iodo-; CAS 1198422-69-3
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Iodo-1-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent quality suitable for sensitive synthetic applications. Comprehensive Certificates of Analysis (COA) with lot-specific data are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.