Description

5-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine is a high-value, heterocyclic boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides with improved efficacy and selectivity.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, due to its fused heterocyclic structure.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in target identification and mechanism-of-action studies.
• Academic & Contract Research: Utilized in universities and CROs for methodological development and the synthesis of complex molecular libraries.
• Scale-up Process Development: Critical for optimizing synthetic routes from milligram to kilogram scale in process chemistry.

Basic Information

Product Name	5-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1198096-23-9
Molecular Formula	C14H19BN2O2
Molecular Weight	258.13 g/mol
Synonyms	5-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methyl-1H-pyrrolo[2,3-b]pyridine; 5-Methyl-1H-pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester; 5-Methyl-3-(pinacolboryl)-1H-pyrrolo[2,3-b]pyridine; 1198096-23-9; 5-Methyl-3-borono-1H-pyrrolo[2,3-b]pyridine pinacol ester
EINECS	Contact for details

Quality Control

Our production of 5-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and lot-to-lot consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive nature. Allow the sealed container to reach ambient temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.