Description

(αr,δs)-4-Fluoro-n-(4-Fluorophenyl)-δ-Hydroxy-α-[(4-Hydroxyphenyl)Methyl]Benzenepentanamide is a sophisticated fluorinated and hydroxylated benzenepentanamide derivative, representing a high-value synthetic intermediate in advanced organic chemistry. Its precise stereochemistry and multifunctional structure make it a critical building block for the development of novel pharmaceutical compounds, particularly in targeted therapeutic areas. This compound is essential for research and development laboratories and production facilities focused on creating next-generation active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disorder research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and scale-up synthesis of potential APIs due to its complex fluorinated aromatic core.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Probe Synthesis: Employed in creating labeled or modified compounds for biological pathway investigation and target validation.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for advanced studies in organic synthesis methodology and asymmetric catalysis.

Basic Information

Product Name	(αr,δs)-4-Fluoro-n-(4-Fluorophenyl)-δ-Hydroxy-α-[(4-Hydroxyphenyl)Methyl]Benzenepentanamide
CAS No.	1197811-72-5
Molecular Formula	C24H21F2NO3
Molecular Weight	409.43 g/mol
Synonyms	4-Fluoro-N-(4-fluorophenyl)-5-hydroxy-5-[(4-hydroxyphenyl)methyl]-2-phenylpentanamide; (Ar,δs)-4-Fluoro-N-(4-fluorophenyl)-δ-hydroxy-α-[(4-hydroxyphenyl)methyl]benzenepentanamide; (Ar,δs)-4-Fluoro-N-(4-fluorophenyl)-δ-hydroxy-α-(4-hydroxybenzyl)benzenepentanamide; CAS 1197811-72-5; Fluorinated Hydroxy Benzenepentanamide Derivative; Benzene pentanamide, 4-fluoro-N-(4-fluorophenyl)-5-hydroxy-5-[(4-hydroxyphenyl)methyl]-; (Ar,δs)-Isomer of 4-Fluoro-N-(4-fluorophenyl)-5-hydroxy-5-(4-hydroxybenzyl)-2-phenylpentanamide
EINECS	Contact for details

Quality Control

Every batch of (αr,δs)-4-Fluoro-n-(4-Fluorophenyl)-δ-Hydroxy-α-[(4-Hydroxyphenyl)Methyl]Benzenepentanamide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing specifications such as chiral purity, chemical purity (by HPLC), and residual solvents are available for each lot. Our quality commitment supports compliance with cGMP guidelines where applicable for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture and atmospheric contamination. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (Ar,δs isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.