Description

2-(2,5-Difluoro-Phenyl)-Pyrrolidine, Hydrochloride is a high-purity, fluorinated pyrrolidine derivative supplied as a hydrochloride salt. This compound serves as a critical pharmaceutical intermediate and building block in advanced organic synthesis, enabling the development of novel active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, leveraging the fluorine substituents for enhanced biological activity and stability.
• Chemical Research & Development: A versatile precursor for creating complex molecular scaffolds in medicinal and process chemistry.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Precursor: Potential intermediate for synthesizing specialty polymers and advanced materials with specific electronic properties.

Basic Information

Product Name	2-(2,5-Difluoro-Phenyl)-Pyrrolidine, Hydrochloride
CAS No.	1197238-95-1
Molecular Formula	C10H11F2N · HCl
Molecular Weight	219.66 g/mol (Free base: 183.20 g/mol)
Synonyms	2-(2,5-Difluorophenyl)pyrrolidine hydrochloride; 1-(2,5-Difluorophenyl)pyrrolidine-2-hydrochloride; Pyrrolidine, 2-(2,5-difluorophenyl)-, hydrochloride; 2,5-Difluoro-2-pyrrolidinylbenzene hydrochloride; 2-(2,5-Difluorophenyl)-1-azacyclopentane hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(2,5-Difluoro-Phenyl)-Pyrrolidine, Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.