Description

4-Bromo-2-(Trifluoromethyl)Acetophenone is a versatile and high-value fluorinated aromatic building block, essential for synthesizing complex organic molecules. Its core value lies in the strategic combination of bromine and trifluoromethyl substituents, which enable precise functionalization and introduce desirable physicochemical properties into target compounds. This intermediate is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of monomers and functional materials, such as liquid crystals and organic semiconductors, where fluorine atoms modulate electronic properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethyl)Acetophenone
CAS No.	1197231-94-9
Molecular Formula	C9H4BrF3O
Molecular Weight	265.03 g/mol
Synonyms	1-(4-Bromo-2-(trifluoromethyl)phenyl)ethan-1-one; 4'-Bromo-2'-(trifluoromethyl)acetophenone; 2-(Trifluoromethyl)-4-bromoacetophenone; 4-Bromo-α,α,α-trifluoro-o-methylacetophenone; p-Bromo-o-trifluoromethylacetophenone; 4-Bromo-2-trifluoromethylacetophenone
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.