Description

n-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is a critical building block in modern synthetic organic chemistry, enabling efficient cross-coupling reactions for the construction of complex molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl and heterobiaryl structures, which are common motifs in drug discovery.
• Pharmaceutical Intermediate: Serves as a versatile precursor in the research and development of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the creation of advanced crop protection agents and herbicides that require specific, complex aromatic architectures.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Acts as a valuable tool compound for bioconjugation and the development of chemical probes to study biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific boronic ester derivatives.

Basic Information

Product Name	n-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide
CAS No.	1197171-76-8
Molecular Formula	C15H22BNO3
Molecular Weight	275.15 g/mol
Synonyms	3-[(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)]-N-methylbenzamide; N-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methyl-benzamide; m-(N-Methylcarbamoyl)phenylboronic acid pinacol ester; Benzoic acid, 3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)]-, methylamide
EINECS	Contact for details

Quality Control

Our n-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture. Recommended storage temperature: 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.