Description

1-[(4-Methylbenzene)Sulfonyl]-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is a high-purity, advanced pharmaceutical intermediate and key building block in modern synthetic chemistry. Its core value lies in its dual functionality, combining a sulfonyl-protected indole scaffold with a pinacol boronate ester group, making it an essential reagent for Suzuki-Miyaura cross-coupling reactions. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester partner for palladium-catalyzed carbon-carbon bond formation, enabling the efficient construction of biaryl and heterobiaryl systems.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require complex heterocyclic cores.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, charge-transport materials, and emissive layers for electronic devices.
• Chemical Biology & Probe Development: Facilitates the creation of labeled compounds and molecular probes for biochemical and diagnostic applications.
• Scale-up & Process Chemistry: Suitable for use in kilogram-scale manufacturing processes under GMP-like conditions for clinical trial material production.

Basic Information

Product Name	1-[(4-Methylbenzene)Sulfonyl]-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	1197026-60-0
Molecular Formula	C21H24BNO4S
Molecular Weight	397.29 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indole; 1-Tosyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 6-(Pinacolatoboryl)-1-tosyl-1H-indole; 1H-Indole, 1-[(4-methylphenyl)sulfonyl]-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-Tosyl-6-Bpin-indole; 6-Bpin-1-tosylindole; Boron, [1-[(4-methylphenyl)sulfonyl]-1H-indol-6-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl-; 1197026-60-0
EINECS	Contact for details

Quality Control

Our production of 1-[(4-Methylbenzene)Sulfonyl]-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole adheres to stringent internal quality standards, ensuring batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. Each lot is fully characterized by NMR (1H, 13C, 11B), HPLC, and mass spectrometry to confirm identity and purity. Comprehensive Certificates of Analysis (COA) detailing all analytical results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (argon or nitrogen) in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.