Description

Sulfamethazine-Phenyl-13C6 Hemihydrate is a stable isotope-labeled internal standard of the sulfonamide antibiotic sulfamethazine, specifically labeled with carbon-13 on the phenyl ring. This compound is critical for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in complex matrices. It is an essential tool for analytical chemists and researchers in pharmaceutical development, food safety, and environmental monitoring who require precise quantification of sulfamethazine residues.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a high-purity internal standard for the accurate quantification of sulfamethazine in biological, food, and environmental samples.
• Pharmaceutical Research & Development: Used in pharmacokinetic, metabolism, and bioequivalence studies to track and measure drug concentrations.
• Food Safety & Veterinary Drug Residue Analysis: Essential for regulatory testing and monitoring of sulfamethazine residues in meat, milk, honey, and other animal-derived products.
• Environmental Monitoring: Applied in the analysis of water and soil samples for antibiotic contamination from agricultural runoff.
• Method Development & Validation: A key component in establishing and validating robust, precise, and compliant analytical methods for regulatory submission.
• Clinical Diagnostics: Supports therapeutic drug monitoring and toxicology studies in human and veterinary medicine.

Basic Information

Product Name	Sulfamethazine-Phenyl-13C6 Hemihydrate
CAS No.	1196157-77-3
Molecular Formula	C1213C6H14N4O2S • ½H2O
Molecular Weight	~287.3 (for unlabeled base)
Synonyms	4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide-phenyl-13C6 hemihydrate; Sulfadimidine-phenyl-13C6 hemihydrate; [Phenyl-13C6]-Sulfamethazine hemihydrate; 13C6-Sulfamethazine internal standard; Isotopically Labeled Sulfadimidine; SMZ-phenyl-13C6; CAS 1196157-77-3
EINECS	Contact for details

Quality Control

Our Sulfamethazine-Phenyl-13C6 Hemihydrate is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and isotopic abundance. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent hydration changes.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom % 13C on phenyl ring
Chemical Purity (NMR)	Conforms
Water Content (KF)	3.0 - 5.0% (consistent with hemihydrate)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.