Description

1-(2,2-Difluoro-Benzo[1,3]Dioxol-5-Yl)-Cyclopropylamine is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorinated benzodioxole scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers seeking to incorporate its distinct fluorinated, constrained-ring structure into new molecular entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for CNS-targeting therapies and enzyme inhibitors.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, leveraging the stability and bioactivity of the difluorobenzodioxole moiety.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and material science applications.
• Chemical Biology Probes: Employed in the design of molecular probes for studying biological pathways and protein interactions.
• Fluorinated Compound Libraries: An essential component for combinatorial chemistry and high-throughput screening libraries focused on fluorinated molecules.

Basic Information

Product Name	1-(2,2-Difluoro-Benzo[1,3]Dioxol-5-Yl)-Cyclopropylamine
CAS No.	1196157-40-0
Molecular Formula	C10H9F2NO2
Molecular Weight	213.18 g/mol
Synonyms	5-(1-Aminocyclopropyl)-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-5-(1-aminocyclopropyl)-1,3-benzodioxole; 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanamine; Cyclopropanamine, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-; 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropylamine
EINECS	Contact for details

Quality Control

Our 1-(2,2-Difluoro-Benzo[1,3]Dioxol-5-Yl)-Cyclopropylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.