Description

2-Bromo-5-Hydroxyisonicotinic Acid is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromine and carboxylic acid functional groups on a pyridine core, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Ligand Synthesis: Used in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Employed in the synthesis of functionalized polymers and organic electronic materials.
• Chemical Biology Probes: Acts as a starting material for creating molecular probes to study biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Bromo-5-Hydroxyisonicotinic Acid
CAS No.	1196156-65-6
Molecular Formula	C6H4BrNO3
Molecular Weight	218.01 g/mol
Synonyms	5-Hydroxy-2-bromopyridine-4-carboxylic acid; 2-Bromo-5-hydroxypyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-bromo-5-hydroxy-; Isonicotinic acid, 2-bromo-5-hydroxy-; 2-Bromo-5-hydroxy-4-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Hydroxyisonicotinic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and NMR/IR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.