Description

2-[2,2-Difluoro-1-(Mem)Ethenyl]Boronic Acid Neopentylglycol Ester is a high-value, protected boronic acid ester derivative, serving as a crucial synthetic intermediate in modern organometallic chemistry. Its primary value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it facilitates the efficient synthesis of novel fluorinated compounds and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those incorporating difluoroalkene or aryl-fluorine motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the Suzuki coupling to create diverse fluorinated bioactive molecules.
• Materials Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs, where fluorination can tune electronic properties.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organoboron catalysts used in asymmetric synthesis and other catalytic processes.
• Chemical Biology & Probe Design: Utilized in the construction of molecular probes and bioconjugates for imaging and diagnostic applications, benefiting from the bioorthogonal nature of the boronic ester group.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical and custom synthesis houses serving the global life sciences industry.

Basic Information

Product Name	2-[2,2-Difluoro-1-(Mem)Ethenyl]Boronic Acid Neopentylglycol Ester
CAS No.	1195886-69-1
Molecular Formula	C10H17BF2O2
Molecular Weight	218.05 g/mol
Synonyms	2-[2,2-Difluoroethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2,2-Difluorovinyl)boronic acid neopentyl glycol ester; 2-(2,2-Difluorovinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B-(2,2-Difluoroethenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Difluorovinylboronic Acid Pinacol Ester; (2,2-Difluoro-1-ethenyl)boronic acid pinacol ester; Mem-difluorovinyl-Bpin; CAS 1195886-69-1
EINECS	Contact for details

Quality Control

Every batch of 2-[2,2-Difluoro-1-(Mem)Ethenyl]Boronic Acid Neopentylglycol Ester is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical characterization using techniques including NMR (¹H, ¹³C, ¹⁹F, ¹¹B), HPLC, and GC to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.