Description

2-(Difluoromethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures with precision. This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce the difluoromethylpyridine moiety into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides, leveraging the difluoromethyl group to enhance biological activity and metabolic stability.
• Suzuki-Miyaura Cross-Coupling: Acts as a versatile boron reagent for palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds, essential for constructing complex heterocyclic compounds.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Fluorine Chemistry: The difluoromethyl group makes it a valuable probe in medicinal chemistry for modulating lipophilicity, metabolic stability, and bioavailability of candidate molecules.

Basic Information

Product Name	2-(Difluoromethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1193104-53-8
Molecular Formula	C13H18BF2NO2
Molecular Weight	269.10 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(difluoromethyl)pyridine; 2-Difluoromethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-(Difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-Pinacolatoboron-2-difluoromethylpyridine; 2-Difluoromethylpyridine-4-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.