Description

1-Bromo-2,3-Bis(trifluoromethyl)benzene is a high-value, multi-functional aromatic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing both halogen and fluorinated motifs into complex molecular architectures, enabling precise tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced synthesis, including cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates requiring fluorinated aromatic systems to enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl groups contribute to improved environmental stability and efficacy.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, facilitating carbon-carbon and carbon-heteroatom bond formation.
• Ligand and Catalyst Development: Employed in the design of novel phosphine or N-heterocyclic carbene (NHC) ligands for transition metal catalysis.
• Fluorine Chemistry Studies: A valuable reagent for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and agrochemistry.

Basic Information

Product Name	1-Bromo-2,3-Bis(trifluoromethyl)benzene
CAS No.	1192548-06-3
Molecular Formula	C8H3BrF6
Molecular Weight	292.99 g/mol
Synonyms	2,3-Bis(trifluoromethyl)bromobenzene; 2-Bromo-1,3-bis(trifluoromethyl)benzene; 1-Bromo-2,3-bis(trifluoromethyl)benzene; Benzene, 1-bromo-2,3-bis(trifluoromethyl)-; 2,3-Bis(trifluoromethyl)-1-bromobenzene; 1-Bromo-2,3-di(trifluoromethyl)benzene; 2,3-Di(trifluoromethyl)bromobenzene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is analyzed to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity (typically by GC or HPLC), identity confirmation (by IR or NMR), and impurity profiles are available upon request. We adhere to a quality management system to guarantee reliable supply and product integrity for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.