Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Propanoic Acid is a versatile and high-purity boronic ester derivative, serving as a crucial building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, catalyst development, and polymer synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific aryl-alkyl linkages.
• Material Science: Precursor for creating functionalized polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes, bioconjugation reagents, and activity-based protein profiling (ABPP) agents.
• Catalyst Ligand Development: Serves as a starting material for synthesizing novel bidentate or monodentate ligands used in homogeneous catalysis.
• Academic & Industrial R&D: A fundamental reagent in organic synthesis laboratories for method development and constructing complex molecular architectures.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Propanoic Acid
CAS No.	1191063-90-7
Molecular Formula	C9H17BO4
Molecular Weight	200.04 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)propionic Acid; 2-(3-Carboxypropyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Propanoic Acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol 3-Carboxypropylboronate; 3-(Pinacolatoboryl)propanoic Acid; 3-Boronopropylpropionic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Propanoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B), and mass spectrometry, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH, FDA GMP (where applicable), and other global regulatory frameworks for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.