Description

3-Bromo-5-Fluorophenylboronic Acid n-Butyldiethanolamine Ester is a specialized organoboron reagent, specifically a protected boronic acid ester. This compound is engineered to offer enhanced stability and handling characteristics compared to its free boronic acid counterpart, making it a valuable intermediate in advanced synthetic chemistry. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly through cross-coupling reactions. Its design addresses the need for reliable, high-purity building blocks in the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for creating biaryl and heterobiaryl structures, which are core scaffolds in many pharmaceuticals and agrochemicals.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Serves as a precursor in the creation of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Can be utilized as a tool compound or linker in the development of biochemical probes and inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specific boronic ester functionalities.

Basic Information

Product Name	3-Bromo-5-Fluorophenylboronic Acid n-Butyldiethanolamine Ester
CAS No.	1190989-06-0
Molecular Formula	C₁₄H₂₀BBrFNO₂
Molecular Weight	344.03 g/mol
Synonyms	3-Bromo-5-fluorobenzeneboronic Acid N-Butyldiethanolamine Ester; B-(3-Bromo-5-fluorophenyl)-N-butyl-N,N-bis(2-hydroxyethyl)borinic Acid Amide Ester; N-Butyldiethanolamine (3-Bromo-5-fluorophenyl)boronate; Boronic Acid, B-(3-Bromo-5-fluorophenyl)-, N-butyl-N,N-bis(2-hydroxyethyl)amine Ester; 3-Bromo-5-fluorophenylboronic Acid N-BDEA Ester
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Fluorophenylboronic Acid n-Butyldiethanolamine Ester is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.