Description

3-Amino-6-Trifluoromethyl-7-Azaindole is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of an electron-donating amino group and a highly electron-withdrawing trifluoromethyl group on the fused azaindole scaffold, enabling precise modulation of molecular properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a privileged intermediate for creating novel active ingredients with optimized potency, metabolic stability, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, anticancer agents, and other small-molecule therapeutics targeting challenging disease pathways.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the CF3 group for enhanced lipophilicity and biological activity.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as OLED emitters or charge-transport layers, due to its tunable electronic properties.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes and tags for studying enzyme function and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring high-fidelity, complex heterocyclic cores.

Basic Information

Item	Detail
Product Name	3-Amino-6-Trifluoromethyl-7-Azaindole
CAS No.	1190320-36-5
Molecular Formula	C8H6F3N3
Molecular Weight	201.15 g/mol
Synonyms	3-Amino-6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 6-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-amine; 3-Amino-6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridin-3-amine, 6-(trifluoromethyl)-; 6-Trifluoromethyl-7-azaindol-3-ylamine
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-6-Trifluoromethyl-7-Azaindole is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with detailed Certificates of Analysis (COA) that include results from HPLC, NMR, and MS. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical development and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.