Description

3-Nitro-6-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functional heterocyclic building block characterized by its nitro and trifluoromethyl substituents. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors where its unique scaffold can impart desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, especially in oncology and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in creating advanced active ingredients for crop protection products, leveraging the trifluoromethyl group for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a building block for organic electronic materials and specialty polymers due to its electron-deficient aromatic system.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic & Institutional Research: Used in universities and research institutes for methodological development and exploration of new chemical spaces.

Basic Information

Product Name	3-Nitro-6-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1190320-06-9
Molecular Formula	C8H4F3N3O2
Molecular Weight	231.14 g/mol
Synonyms	3-Nitro-6-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-nitro-6-(trifluoromethyl)-; 6-(Trifluoromethyl)-3-nitro-1H-pyrrolo[2,3-b]pyridine; 3-Nitro-6-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; Pyrrolopyridine nitro trifluoromethyl derivative; CAS 1190320-06-9
EINECS	Contact for details

Quality Control

Our 3-Nitro-6-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and reliable supply chain integrity makes us a trusted partner for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.